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desvenlafaxine will enhance the level or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Watch. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, 400 mg) lessen the CYP2D6 substrate dose by up to fifty%; no dosage adjustment desired with desvenlafaxine doses seven consecutive times right away ah

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